The Eye and The Chip 2021

Deep Learning Techniques to Classify Retinal Degeneration in Histological Sections

Daniel Al Mouiee1,2,3, Erik Meijering2, Michael Kalloniatis4, Lisa Nivison-Smith4, Richard A Williams5 David AX Nayagam5,6, Thomas C Spencer6,7, Chi D Luu8,9, Ceara McGowan6, Stephanie B Epp6, Mohit N Shivdasani1,6 – 1Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW, Australia – 2School of Computer Science and Engineering, University of New South Wales, Kensington, NSW, Australia – 3School of Biotechnology and Biomolecular Science, University of New South Wales, Kensington, NSW, Australia – 4School of Optometry and Vision Sciences, University of New South Wales, Kensington, NSW, Australia – 5Department of Pathology, University of Melbourne, Parkville, VIC, Australia – 6The Bionics Institute of Australia, East Melbourne, VIC, Australia – 7Department of Biomedical Engineering, University of Melbourne, Parkville, VIC, Australia – 8Ophthalmology, Department of Surgery, University of Melbourne, Parkville, VIC, Australia – 9Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia

Comparison of Optical Transparency and Hermeticity of Various Polymers for Retinal Prosthesis

Changhoon Baek and Jong-mo Seo* Seoul National University

Characterization of Retinal Simulation and Integration with a Subretinal Honeycomb-shaped Prosthesis

Mohajeet B. Bhuckory1,2, Zhijie Charles Chen1,3, Bing-Yi Wang1, Tiffany Huang3, Ludwig Galambos1, Andrew Shin4, Theodore Kamins3, and Daniel Palanker1,2 1Hansen Experimental Physics Laboratory, 2Ophthalmology, 3Electrical Engineering, 4Material Science, Stanford University, Stanford, CA

Electrical Stimulation Synchronizes Activity Over Space and Time in the Degenerating Retina

Maya Carleton & Nicholas W Oesch. Department of Psychology and Department of Ophthalmology, University of California San Diego, La Jolla, CA, 92093, USA

A Computational Model for Cortical Simulation Comparing Realistic Electrode Geometry vs. a Point Source

MAHMUT EMIN CELIK1,2, KATHLEEN E. KISH2, JAMES WEILAND2 ELECTRICAL ELECTRONICS ENGINEERING DEPARTMENT, FACULTY OF ENGINEERING, GAZI UNIVERSITY, TURKEY BIOELECTRONIC VISION LAB, DEPARTMENT OF BIOMEDICAL ENGINEERING, UNIVERSITY OF MICHIGAN

Interaction Between PC12 Cells and 3D Carbon Pillar Electrodes for Subretinal, Photovoltaic Prosthesis

Rasmus Schmidt Davidsen*1, 2, Alice le Friec3, Stephan S. Keller2, Toke Bek1 1Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark, 2DTU Nanolab, Technical University of Denmark, Denmark, 3Aarhus University, Department of Medical Biotechnology *Corresponding Author: rasda@dtu.dk

Intraretinal Stimulation with Carbon Fiber Electrodes

ELENA DELLA VALLE1, DORSA HAJI-GHAFFARI1, PARAS PATEL2, CYNTHIA CHESTEK2, JAMES D. WEILAND1 1BIOELECTRONIC VISION LAB, DEPARTMENT OF BIOMEDICAL ENGINEERING, UNIVERSITY OF MICHIGAN 2CORTICAL NEURAL PROSTHETICS LAB, DEPARTMENT OF BIOMEDICAL ENGINEERING, UNIVERSITY OF MICHIGAN

Towards Calibrated Computer Models for the Optimization of Parallel Stimulation

S.C. Eggenberger, A.M. Pratiwi & G.J. Suaning sydneyBIONICS laboratory, The University of Sydney, Australia

Learning to See Again: Perceptual Learning of Abnormal On-off Cell Population Responses Produced by Sight Recovery Technologies

Rebecca Esquenazi1, Michael Beyeler2,3, Geoffrey Boynton1, & Ione Fine1 1Department of Psychology, University of Washington; 2Department of Psychological and Brain Sciences, University of California, Santa Barbara; 2Department of Computer Science, University of California, Santa Barbara

A Simple Computational Model of Phosphene Appearance for Epiretinal Prostheses

Jacob Granley, Michael Beyeler University of California, Santa Barbara

A Real-time Image Optimization Algorithm for PRIMA Patients

Elton Ho1,2 and Daniel Palanker2,5 – 1Hansen Experimental Physics Laboratory, – 2Ophthalmology, Stanford University, CA

Evaluation of Information Needs of Blind Pedestrians Performing Urban Mobility Tasks

Karst M.P. Hoogsteen† - Schepens Eye Research Institute, Mass Eye and Ear, Harvard Medical School, USA Sarit Szpiro - Department of Special Education, University of Haifa, Israel Gabriel Kreiman - Boston Children’s Hospital, Harvard Medical School, Center for Brains, Minds, and Machines, USA Eli Peli - Schepens Eye Research Institute, Mass Eye and Ear, Harvard Medical School, USA

Imaging Action Potentials Across Retinal Ganglion Cells in Retinal Degenerative RD1 Blind Mice

Younginha Jung,* Sungmoo Lee,† Jun Kyu Rhee,†, ‡ Chae-Eun Lee,* Bradley J. Baker,†, ‡ and Yoon-Kyu Song * * Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, † Brain Science Institute, Korea Institute of Science and Technology, Seoul, South Korea, ‡ Division of Bio-Medical Science and Technology, Korea University of Science and Technology, Seoul, South Korea

Object Rankings and Notification Preferences for an Object Finder System Among People with Native and Artificial Ultra Low Vision

Kartha, Arathy1 ; Sadeghi, Roksana1,2 ;Singh, Nikki5; Ju, Suyeon5; Chamberlain, Ryan3; Kramer, Kevin3; Gibson, Paul4; Lee, Soo Hyun1; Dagnelie, Gislin1 1. Wilmer Eye Institute, Baltimore, MD, United States. 2. Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States. 3. Minnesota Health Solutions, MN, United States 4. Advanced Medical Electronics, MN, United States 5. Johns Hopkins University, Baltimore, MD, United States

Biocompatibility and Neural Stimulation Capacity of Aluminum Nanocrystal Integrated Biointerfaces for Use in Artificial Vision

Cem KESIM1, Mertcan HAN2, Erdost YILDIZ3,4, Houman BAHMANI JALALI5, Mohammad Haroon QURESHI3, Murat HASANREISOGLU1,3, Sedat NIZAMOGLU2 & Afsun SAHIN1,3 1Department of Ophthalmology, Koç University School of Medicine, Istanbul, TURKEY; 2Department of Electrical and Electronics Engineering, Koç University, Istanbul, TURKEY; 3Koç University Research Center for Translational Medicine, Istanbul, TURKEY; 4Department of Physical Intelligence, Max Planck Institute for Intelligent Systems, Stuttgart, GERMANY; 5Department of Photonic Nanomaterials, Istituto Italiano di Tecnologia, Genoa, ITALY

Developing Realistic Models of Retinal Stimulation

KATHLEEN E. KISH1, JAMES D. WEILAND1,2 1DEPARTMENT OF BIOMEDICAL ENGINEERING 2DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES; UNIVERSITY OF MICHIGAN

Surgical Method for Chronic Rodent Epiretinal Implant Model

Beomseo Koo1, Eugene Yoon, Ph.D.2, Nikolas Barrera2, Ellis Meng Ph.D.2 and James Weiland, Ph.D.1 1. Department of Biomedical Engineering, University of Michigan, 2. Department of Biomedical Engineering, University of Southern California

Variability in Absolute Phosphene Mapping Techniques: Finger vs. Gaze Coordinates

Lee, Soo Hyun; Yang, Liancheng; Sun, Helen; Sargur, Krishna; Diaz, William; Ju, Suyeon; Sadeghi, Roksana; Kartha, Arathy; Dagnelie, Gislin Johns Hopkins University School of Medicine, Baltimore, MD, USA

Newcastle Visual Cortical Prosthesis - Control System

Yu Liu, Patrick Degenaar School of Engineering, Newcastle University, UK

A Generic Model of Neural Retina for Investigating Retinal Network Response to Electric Stimulation

Keith Ly, Tianruo Guo, Madhuvanthi Muralidharan, David Tsai, Mohit Shivdasani, Nigel H. Lovell

Effect of Tunnel Vision Blindness on Brain Connectivity

Negin Nadvar, Jeiran Choupan, Noelle Stiles, Vivek Patel, Yonggang Shi, Hossein Ameri, John Jonides, James Weiland

Effect of Spike-shaped Array on Electrode Position Fluctuation of Suprachoroidal Retinal Prosthesis

Yukari Nakano1, Junichiro Shikata1, Yasuo Terasawa1 and Tokio Ueno2 1Artificial Vision Institute, R&D Div., Nidek Co.,Ltd., Gamagori, Japan., 2R&D Div., Nidek Co.,Ltd., Gamagori, Japan.

High-efficiency CMOS-based Wireless Power and Data Transceiver and Stimulator for Artificial Retina

Jisung Kim1, Hyunbeen Jeong1, Jong-mo Seo1,2, Anderea Neviani3 1Deparment of Electrical and Computer Engineering, Seoul National University, 2Seoul National University Hospital, 3Department of Information Engineering, University of Padova

Multi-electrode Stimulation Evokes Consistent Spatial Pattern of Phosphenes and Improves Phosphene Mapping in Blind Subjects Implanted with the Second Sight Orion Cortical Visual Prosthesis

Long-term Reliability of the Orion Visual Cortical Prosthesis

Uday Patel1, Jessy D. Dorn1, Nader Pouratian2, Daniel Yoshor3, Robert Greenberg4, Michelle Armenta Salas5, Soroush Niketeghad5, Denise Oswalt3, William Bosking3 1Second Sight Medical Products, Inc. 2University of Texas Southwestern 3University of Pennsylvania 4Alfred E. Mann Foundation 5University of California, Los Angeles

Optimized Stimulation Paradigms for Electrical Retinal Implants: The Combination of Voltage Pulse Polarity and Reference Electrode Distance Yield Distinctive Ganglion Cell Response Patterns

Lucia Peiroten, Eberhart Zrenner, Wadood Haq Institute for Ophthalmic Research, University of Tuebingen

Developing a Rabbit Model of Monocular Retinal Degeneration for Vision Restoration Applications

Hallur Reynisson, Lisa Nivison-Smith, Naomi Craig, Nigel H. Lovell, Michael Kalloniatis, Mohit Shivdasani

Number of Brightness Levels That Can be Distinguished by Visual Prosthesis Users

Sadeghi, Roksana; Bradley, Chris; Barry, Michael P.; Kartha, Arathy; Dagnelie, Gislin Wilmer eye institute, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Splaying Arrays for Stimulation of LGN and Cortex

Doug Shire, PhD and Marcus Gingerich, PhD, Bionic Eye Technologies, Inc., Ithaca, NY USA Shelley Fried, PhD, Seungwoo Lee PhD and Sang Baek Ryu, PhD, Massachusetts General Hospital, Boston, MA USA Joseph F. Rizzo MD, Massachusetts Eye and Ear, Boston, MA USA

The Effect of Sustained Electrical Stimulation on the Retinal Gap-Junction-Coupled Lateral Pathways in the RD1 Mouse Model for Retinal Degeneration

Sophie Stürmer, Eberhart Zrenner, Wadood Haq Institute for Ophthalmic Research, University of Tübingen

Bi-electrode Epiretinal Stimulation at Cellular Resolution for Axon Avoidance

Ramandeep Vilkhu1, Sasi Madugula1, Lauren E. Grosberg1, Pawel Hottowy2, Alexander Sher3, Alan M. Litke3, Subhasish Mitra1 and E.J. Chichilnisky1 1Stanford University, Stanford, CA 94305, USA; 2AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, 30059 Krakow, Poland; 3Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

Enhancing the Biocompatibility of Intracortical Microelectrodes by Controlled Release of Dexamethasone using Nanostructured Lipid Carriers

Villamarín-Ortiz, Marcos Adrián1; Lafuente, Markel3; Pedraz, José Luis3; Soto-Sánchez, Cristina1, 2; Fernández, Eduardo1, 2. 1. Neuroprosthesis and Visual Rehabilitation Unit, Bioengineering Institute, Miguel Hernández University of Elche, Spain; 2. Histology and Anatomy Department, Bioengineering Institute, Miguel Hernández University of Elche, Spain.; 3. NanoBioCel: Micro and nano Technologies, biomaterials and cells research group, Pharmacy and Pharmaceutical Science's Department, University of The Basque Country (UPV/EHU), Spain

Subretinal Planar and 3D Photovoltaic Arrays Enable Prosthetic Vision Matching the Natural Acuity of 27 μm in Rats

Bing-Yi Wang1*, Mohajeet Bhuckory3, Charles Chen2, Tiffany Huang2, Andrew Shin5, Ludwig Galambos2, Valentina Zuckerman4, Elton Ho1, Keith Mathieson6, Theodore Kamins2, and Daniel Palanker3,4 – 1Physics, 2Electrical Engineering, 3Ophthalmology, 4Hansen Experimental Physics Lab, Material Science, Stanford U; 6Physics, Unversity of Strathclyde

Deep Learning–based Scene Simplification Can Improve Prosthetic Vision Quality: A Study with Simulated Prosthetic Vision

Aiwen Xu, Nicole Han, Sudhanshu Srivastava, Devi Klein, Michael Beyeler University of California, Santa Barbara

Thermophysical Optimization of the Optogenetic Visual Prosthesis

Hongze Zhong*, Anthony O’Neill, Patrick Degenaar School of Engineering, Newcastle University, UK

Shape Changing Polymer Bilayer for Implanted Epiretinal Flexible Electronics

Muru Zhou, Do Hyun Kang, James D. Weiland, Jinsang Kim